Pivotal Clinical Trials of Migraine Drugs: Are We Measuring the Same Thing?
By Neil Andrews |
An analysis of dozens of trials reveals important differences in endpoint selection and timing.
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Join the Migraine Science Collaborative by becoming a member! Membership gives you the opportunity to contribute to the site, and it helps build community and raise awareness of headache conditions. Visit here to sign up for free.
The Burden of Chronic Pain: Many New Cases, Lots of Persistence
By Kayt Sukel |
In the first study of its kind, researchers examine chronic pain incidence and persistence in a nationally representative sample of adults in the United States. It's likely the burden of pain is much higher than reported in the study when taking migraine into account.
Responding to Patient Questions: Is an AI Chatbot Better Than a Doctor?
By Kayt Sukel |
A new study shows that ChatGPT provides higher-quality and more empathetic answers. Like healthcare professionals in other fields, those who care for people with migraine and headache need to take stock of this disruptive technology.
A Neuroimmune Signaling Pathway Drives Chronic Headache
By Fred Schwaller |
A new study in mice finds that CCL2-CCR2 signaling in macrophages and T cells sensitizes trigeminal ganglion neurons, driving chronic headache in migraine models. With synergistic effects on CGRP, the pathway could be a new therapeutic target for migraine.
The Latest Papers from MSC's Biweekly Literature Recap
Posted in Papers / Original Research / Editor's Picks / Animal Studies /Â September 16-30, 2023
Effects of chronic caffeine on patterns of brain blood flow and behavior throughout the sleep–wake cycle in freely behaving mice
Posted on September 29, 2023
Posted in Papers / Reviews / Editor's Picks /Â September 16-30, 2023
Migraine in older adults
Posted on September 29, 2023
Posted in Papers / Reviews / Editor's Picks /Â September 16-30, 2023
Menstrual migraine is caused by estrogen withdrawal: revisiting the evidence
Posted on September 29, 2023
Posted in Papers / Original Research / Human Studies / Editor's Picks /Â September 1-15, 2023
Discovery and characterization of prolactin neutralizing monoclonal antibodies for the treatment of female-prevalent pain disorders
Posted on September 15, 2023
Posted in Papers / Original Research / Editor's Picks / Animal Studies /Â September 1-15, 2023
PACAP38-related modulation of the cranial parasympathetic projection: a novel mechanism and therapeutic target in severe primary headache
Posted on September 14, 2023
Posted in Papers / Editor's Picks / Commentaries /Â September 1-15, 2023
Aura is a symptom of a migraine attack, not its cause
Posted on September 14, 2023
Multimedia
The Role of Lifestyle Factors in Migraine and How to Implement Behavioral Change: A Podcast with Elizabeth Seng
By Kayt Sukel |
In this MSC podcast, Elizabeth Seng discusses how lifestyle factors, including stress, sleep, diet, and physical activity contribute to migraine, and the best way to implement behavioral change to improve the lives of people who have this disorder.
Behavioral Therapies for Migraine: A Podcast with Dawn Buse
By Fred Schwaller |
In this MSC podcast, Dr. Dawn Buse discusses how she began her career as a migraine researcher and clinical psychologist, the use of behavioral therapies for migraine, and some of her most important epidemiological research findings to date.
The Untapped Opportunity to Better Understand Migraine in Children and Adolescents: A Podcast with Serena Orr
By Kayt Sukel |
In this MSC podcast, Serena Orr discusses her path to pediatric migraine research, some of her recent work on the role of anxiety and depression in kids with migraine, how adverse childhood experiences affect pediatric migraine, as well as the need for more funding of headache research.