Posts by Fred Schwaller
Psychedelics to Treat Human Disease: Many Targets, Lots of Complexity
Researchers have created a pharmacological “library” of psychedelic drugs and identified the receptors they activate. The new resource could aid the development of safer and more effective compounds, including for headache disorders.
Using Machine Learning to Predict the Course of Post-traumatic Headache
A model relying on electronic headache diary data accurately classified study participants into subgroups with different headache trajectories after a mild traumatic brain injury.
Sex Differences in Migraine and Pain: A Podcast with Frank Porreca
In this MSC podcast, Dr. Porreca discusses his career path, some of his recent research on sex differences in migraine and pain, and more.
CBD and THC for Migraine Treatment: A Study in Mice Says Working Together Is Better Than Working Alone
New research finds that a 100:1 ratio of CBD to THC effectively reduces migraine-like symptoms in three preclinical models of migraine. The results could help clinical investigators as they test the drugs in patients.
An Outlook on CGRP Therapies for Migraine: A Conversation with Antoinette Maassen van den Brink
In this Migraine Science Collaborative interview, Antoinette Maassen van den Brink discusses the role of sex hormones in migraine, her ongoing work to understand possible side effects of CGRP therapies, and the challenge of access to these drugs.
A Key Migraine Mechanism Is Responsible for Endometriosis Pain
CGRP signaling from neurons to immune cells drives endometriosis pain and lesion growth, suggesting that CGRP-blocking drugs could be a potential treatment for the condition.
A Telehealth Mindfulness-Based Intervention for Pain: Effective and Practical
A randomized clinical trial in more than 800 veterans, including some with headache, showed that the intervention was effective, whether delivered in group sessions or as a self-paced program.
A Newly Discovered Neural Circuit for Placebo Pain Relief
In a long-sought breakthrough, researchers have delineated a pathway, from the cortex to the pontine nucleus and cerebellum, that governs pain relief from positive expectations, in a mouse study.
Nociceptors Function Differently in Males versus Females – Whether in Mice, Monkeys, or People
A new study in multiple species reveals sex differences in prolactin and orexin B sensitization of nociceptors. The novel finding may help to explain sex differences in the prevalence of many chronic pain disorders – and migraine, too.
Using Artificial Intelligence to Advance Migraine Care, Treatment and Research: A Podcast with Chia-Chun Chiang
In this MSC podcast, Dr. Chiang discusses her interest in using AI to address important questions in the migraine field, her research findings in this area, and much more.
