News

Chronic pain and substance use disorders.
News

Chronic Pain and Substance Use Disorders Have Shared Genetics

A new study includes data from more than 800,000 people with chronic pain, with lessons for the migraine field, too.
Read More
Brain imaging of chronic pain.
News

A Lesson from Brain Imaging: Head Pain Is Different from Other Kinds of Chronic Pain

A new neuroimaging study pinpoints differences in gray matter in those with chronic pain, especially multisite pain, compared to healthy individuals. Those who reported head pain showed unique differences compared to other chronic pain types.
Read More
COVID-19 and pediatric pain.
News

Pain in Children: A COVID-19 Paradox

A new analysis shows decreased prevalence of pediatric chronic pain during the first year of the pandemic, compared to 2019. Less school bullying, as well as higher family resilience and more frequent family meals, may have contributed to the surprising finding.
Read More
Trigeminal ganglion clock
News

The Ticking of the Trigeminal Ganglion Clock during Headache

A new study identifies circadian features of trigeminal ganglion cells and animal pain responses. These features are reflected at a genetic level, too, which could set the stage for improved headache treatment.
Read More
Migraine-related stigma
News

New Evidence That It’s Time to OVERCOME Migraine Stigma

A population-based study, OVERCOME, reveals that a large number of people living with migraine experience stigma – and a poorer quality of life as a result.
Read More
Retinal vasculature
News

Looking Migraine in the Eye

A non-invasive imaging tool reveals changes in the retinal microvasculature during migraine. The approach could help researchers better understand the pathophysiology of the condition and perhaps be of clinical use, too.
Read More
Big data and acute migraine medications
News

Which Acute Migraine Medications Work Best? Taking a Big Data Approach

Researchers use e-diary smartphone data for head-to-head comparisons of 25 acute migraine medications. Reassuringly, the results are consistent with current clinical guidelines.
Read More
Environmental irritants, migraine, and TRPA1
News

Environmental Chemicals Can Trigger Migraine Signaling

A proof-of-concept study in mice shows that pesticides and pollutants activate migraine signaling pathways via the ion channel TRPA1. It’s unclear if the findings relate to migraine in people.
Read More
CGRP and migraine prodrome.
News

Treating Migraine Before It Begins with a CGRP Inhibitor

A new trial shows that ubrogepant, a small-molecule calcitonin gene-related peptide receptor antagonist, prevents headache when taken during the prodrome phase. The findings have large clinical implications.
Read More
Anti-prolactin antibody for migraine and pain
News

A Novel Prolactin Antibody Prevents Pain Behaviors in Female Mice

The new approach paves the way for a better understanding of prolactin in female-predominant conditions, including migraine and pain disorders. But targeting prolactin as a potential treatment approach in people faces significant challenges.
Read More