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A New Approach to Migraine Treatment: Found in Translation?

A preclinical study reports that targeting an enzyme with a crucial role in protein synthesis improves hypersensitivity in rodent models of migraine. The strategy has promising therapeutic potential to treat migraine in people.
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Triptan responders and non-responders
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The Response to Triptans: What Counts as Success? What Counts as Failure?

A consensus panel of the European Headache Federation provides definitions of triptan responders and non-responders. The effort could improve migraine treatment and standardize research.
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Improving Headache Diagnosis with Artificial Intelligence

A recent proof-of-concept study shows that natural language processing and machine learning can accurately classify migraine versus cluster headache.
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Why Does Sumatriptan Only Work for Headache Disorders?

A new study further advances the case that the drug suppresses central sensitization, acting only in the trigeminal nociceptive system.
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When a Migraine Lasts for Days: Gaining a Sense of the Scope of the Problem

A new study provides the first population-based estimate of the incidence of status migrainosus.
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Racial and Ethnic Disparities in Chronic Pain, Including Migraine: More Than Black versus White

A new study examines pain prevalence in Black, White, Hispanic, Asian, multiracial and Native American adults in the United States. The work finds that differences between Black and White groups pale in comparison to differences between other racial/ethnic groups.
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Vascular risk score and migraine.
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Understanding the Links Between Migraine and Vascular Health

A new study finds that higher vascular risk scores are associated with lower chances of active or incident migraine.
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Mindfulness and Migraine: Is There a Link?

A new replication and extension study finds little to connect the trait of mindfulness with pain in healthy controls, nor is it associated with improvements in headache in people with migraine.
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A Better Way to Classify Migraine: Linking Symptoms to Patterns of Brain Activity

“Episodic” versus “chronic” migraine is not a biologically meaningful distinction, according to a new fMRI study.
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Eye squinting as an automated readout of pain.
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More Than Meets the (Human) Eye: Headache Researchers Use Facial Detection Software as an Automated Readout of Pain in Mice

The new approach accurately detects squinting in response to CGRP and amylin, and proves superior to a manual strategy.
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