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Nitric oxide and migraine
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Solidifying the Link Between Nitric Oxide and Migraine

Two recent studies – one in people, one in animals – build the case for aberrant nitric oxide signaling in the pathophysiology of migraine. Experiments in mice implicate sex differences in mitochondrial function.
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Migraine and pregnancy
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The Impact of Migraine History and Medication Use on Pregnancy Outcomes

Recent studies contribute valuable findings by looking to two unique datasets.
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Medication overuse headache.
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PACAP Signaling: A New Mechanism of Medication Overuse Headache from Opioids?

A recent animal study shows that inhibiting pituitary adenylate cyclase-activating polypeptide alleviates medication overuse headache following morphine. The findings have interesting translational potential.
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Self-management as a migraine treatment.
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CHESS – A Negative Trial of Self-Management as a Migraine Treatment: What’s the Next Move?

Findings from the Chronic Headache Education and Self-management Study (CHESS) showed that self-management did not improve migraine symptoms, but there is reason for optimism, nonetheless.
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The geography of pain.
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The Geography of Pain: Country versus Country, Province versus Province, State versus State

A recent study comparing pain levels between the US and Canada highlights the importance of socioeconomic status as a contributor to pain, as do subnational analyses in each country.
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Sex differences in cluster headache.
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“Women Can Get Cluster Headache Too”

The largest study so far of sex differences in cluster headache reports that more women than men experienced the chronic form of this condition, as well as longer bouts.
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Psilocybin for cluster headache.
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Promising Signs for Psychedelic Use in Cluster Headache

A small study finds that low-dose psilocybin was safe and had a moderate effect size, though results did not reach statistical significance.
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Is alcohol a migraine trigger?
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Is Alcohol a Migraine Trigger?

A new prospective cohort study reports that alcohol does not trigger migraines, even suggesting that in some instances, it is associated with a lower probability of a migraine attack.
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Headache Disorders in Veterans: A Big Problem

Two recent studies highlight the impact of headache and migraine in US veterans, with a focus on gender differences and other factors.
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A New Approach to Migraine Treatment: Found in Translation?

A preclinical study reports that targeting an enzyme with a crucial role in protein synthesis improves hypersensitivity in rodent models of migraine. The strategy has promising therapeutic potential to treat migraine in people.
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