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Trigeminal ganglion clock
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The Ticking of the Trigeminal Ganglion Clock during Headache

A new study identifies circadian features of trigeminal ganglion cells and animal pain responses. These features are reflected at a genetic level, too, which could set the stage for improved headache treatment.
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Migraine-related stigma
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New Evidence That It’s Time to OVERCOME Migraine Stigma

A population-based study, OVERCOME, reveals that a large number of people living with migraine experience stigma – and a poorer quality of life as a result.
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Retinal vasculature
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Looking Migraine in the Eye

A non-invasive imaging tool reveals changes in the retinal microvasculature during migraine. The approach could help researchers better understand the pathophysiology of the condition and perhaps be of clinical use, too.
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Big data and acute migraine medications
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Which Acute Migraine Medications Work Best? Taking a Big Data Approach

Researchers use e-diary smartphone data for head-to-head comparisons of 25 acute migraine medications. Reassuringly, the results are consistent with current clinical guidelines.
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Environmental irritants, migraine, and TRPA1
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Environmental Chemicals Can Trigger Migraine Signaling

A proof-of-concept study in mice shows that pesticides and pollutants activate migraine signaling pathways via the ion channel TRPA1. It’s unclear if the findings relate to migraine in people.
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CGRP and migraine prodrome.
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Treating Migraine Before It Begins with a CGRP Inhibitor

A new trial shows that ubrogepant, a small-molecule calcitonin gene-related peptide receptor antagonist, prevents headache when taken during the prodrome phase. The findings have large clinical implications.
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Anti-prolactin antibody for migraine and pain
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A Novel Prolactin Antibody Prevents Pain Behaviors in Female Mice

The new approach paves the way for a better understanding of prolactin in female-predominant conditions, including migraine and pain disorders. But targeting prolactin as a potential treatment approach in people faces significant challenges.
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migraine rare variants
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A Genetic Deep Dive to Find What’s Rare in Migraine

A GWAS meta-analysis uncovers rare genetic variants, with large effects, associated with migraine. The research also pinpoints variants unique to different migraine subtypes.
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PACAP and post-traumatic headache.
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PACAP: A New Target for Treatment of Post-Traumatic Headache?

A recent randomized clinical trial builds the case for pituitary adenylate cyclase-activating polypeptide-38 in the pathophysiology of PTH.
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migraine aura
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Does Aura Really Initiate Migraine Attacks? Challenging the Conventional Wisdom

Neuroimaging findings from a single patient suggest that aura may be an epiphenomenon, with no causal role in the onset of an attack.
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