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Basic science year in review
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The Year in Basic Science Migraine Research: 2023 Highlights

New animal studies in 2023 enhanced knowledge of the pathophysiological mechanisms underlying migraine and headache disorders, again showing the value of fundamental research for the field.
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Caffeine and migraine
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New Insight into Caffeine’s Effects on Wakefulness, Sleep, and Brain Blood Flow

Researchers use a microchip/video system to show that chronic caffeine in mice has complex effects throughout the sleep–wake cycle and a paradoxical impact on brain blood flow. The findings have implications for understanding migraine as well as neurodegenerative diseases.
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Heading in the wrong direction.
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The State of Migraine Care in the UK: Long Waiting Times, Inconsistent Medication Access, and Not Enough Training

A new report from The Migraine Trust pulls together data from multiple sources to show that migraine care in UK nations is lacking. The situation is likely similar in the US and other regions, too.
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Second messenger signaling and migraine
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Shifting Attention from the Outside to the Inside of the Cell during Migraine

New research shows that second messenger signaling spurs migraine attacks even in the presence of CGRP receptor blockade.
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Meninges
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P2X7 Signaling Contributes to Meningeal Sensitization

Researchers provide a new explanation for how cortical spreading depression affects afferent nociceptive neurons in the meninges.
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Image vs. Reality: What Does a Migraine Attack Really Look Like?

A new study finds that popular stock images depicting a migraine attack are not realistic, nor are they representative of how people view their own attacks.
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Clinical trial endpoints of migraine drugs.
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Pivotal Clinical Trials of Migraine Drugs: Are We Measuring the Same Thing?

An analysis of dozens of trials reveals important differences in endpoint selection and timing.
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A new study uses machine learning to predict the development and spread of chronic pain based on a shared set of mental health, sociodemographic, and physical health factors.
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Shared Biopsychosocial Factors Underlie Many Different Types of Chronic Pain, Including Headache

A new study uses machine learning to predict the development and spread of chronic pain based on a shared set of mental health, sociodemographic, and physical health factors.
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Top 10 Migraine Science Collaborative news stories
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The Migraine Science Collaborative Celebrates Its One-Year Anniversary: What Were You Reading over the Past Twelve Months?

One year after the launch of the new MSC website, news stories on psychedelics, CGRP inhibition, and artificial intelligence take the first three spots in our Top 10 list.
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Chronic pain incidence and persistence.
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The Burden of Chronic Pain: Many New Cases, Lots of Persistence

In the first study of its kind, researchers examine chronic pain incidence and persistence in a nationally representative sample of adults in the United States. It's likely the burden of pain is much higher than reported in the study when taking migraine into account.
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