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AI-ECG
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Modern Technology Applied to a Traditional Approach: A New Way to Assess Atrial Fibrillation Risk in Migraine Patients

A large study of 40,000 people with migraine shows that an artificial intelligence-enabled electrocardiogram predicts an increased risk of atrial fibrillation in patients with migraine with aura.
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Large clinical trial shows efficacy and safety of e-TNS
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Large Clinical Trial Shows Efficacy and Safety of External Trigeminal Nerve Stimulation for Migraine Treatment

A study of more than 500 patients across 10 sites in the US reaches its primary outcomes of pain freedom and resolution of most bothersome symptoms. Does this pave the way for more widespread clinical use of neuromodulation?
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New Links Between Blood Proteins and Migraine
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New Links Between Blood Proteins and Migraine

A genetic study reveals that five of the proteins show a causal relationship with migraine risk.
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A Drug That Boosts Naturally Occurring Opioids Eases Migraine Pain in an Animal Model.
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A Drug That Boosts Naturally Occurring Opioids Eases Migraine Pain in an Animal Model

PL37, which inhibits the enzymes that degrade enkephalins, reduces migraine pain in rats.
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Migraine prevalence
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One in Two People Experience a Headache Disorder, an Updated Review Reports

New research extends upon the Global Burden of Disease study, finding that the prevalence of migraine has increased over time.
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Trigemenial ganglia cell atlas
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Location, Location, Location: Finding the Way to the Cell Types and Genes That Contribute to Migraine

A new trigeminal ganglia cell atlas in mice and people highlights the multiple cell types – both neuronal and non-neuronal – that are involved in migraine. The findings hold promise for the development of new migraine treatments.
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Adverse childhood experiences and migraine risk
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Adverse Childhood Experiences Increase the Risk of Migraine in Adolescents

A new prospective study documents a direct relationship between ACEs and migraine, independent of depression or anxiety.
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Schwann cells and migraine
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Are Schwann Cells the Bad Guys of Migraine Pain?

New findings in mice show that CGRP activates Schwann cells to sensitize trigeminal neurons, leading to migraine-like pain.
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Migraine GWAS
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Researchers Discover New Genetic Variants for Migraine

The largest genome-wide association study so far reveals new variants associated with migraine risk, including variants linked to specific migraine subtypes.
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PACAP Goes Its Own Way in Migraine

A new study reports that the PACAP signaling pathway is independent from the CGRP pathway, confirming the promise of PACAP as a drug target for migraine treatment.
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